By Yin-Tak Woo, David Y. Lai, Joseph C. Arcos
Chemical Induction of melanoma: Structural Bases and organic Mechanisms, quantity IIIB: Aliphatic and Polyhalogenated cancer agents covers environmentally and occupationally major cancer causing agents of business origins.
The e-book discusses the structure-activity relationships, metabolism, and environmental importance of the halogenated linear alkanes and alkenes and the halogenated cycloalkanes; and cycloalkene insecticides, biphenyls, and similar aromatics. The textual content additionally describes the structure-activity relationships, metabolism, and environmental importance of the halogenated phenoxy acids, fragrant ethers, dibenzofurans, and dibenzo-p-dioxins; and ethylene glycol, diethylene glycol, dioxane, and comparable compounds. The structure-activity relationships, metabolism, and environmental importance of phenols and phenolic compounds; nitroalkanes and nitroalkenes; and acetamide, dimethylcarbamyl chloride, and similar compounds thiocarbonyl compounds also are encompassed. The e-book extra tackles the structure-activity relationships, metabolism, and environmental value if fatty acids, detergents, and different surfactants with oncogenic strength. The textual content then appears into the impression of chemical reactivity, molecular geometry, and metabolism on carcinogenic job.
Chemists, geneticists, and people interested by melanoma learn will locate the publication precious.
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Additional info for Aliphatic and Polyhalogenated Carcinogens. Structural Bases and Biological Mechanisms
Trichloroe thylene Standard + n. t. t. t. t. 3,4-Dichloro-l-butène Enclosed + (74) + (74+) l-Chloro-2-butenef Suspension + (72) + (72") 2-Chloro-2-butenee Suspension - (72) + (72+) l-Chloro-2-methyl-2-butenef Suspension + (72) + (72") l,3-Dichloro-2-butenee>f Standard - (166) - (166) 1,4-Dichloro-2-butene Standard + (74) + (74+) Enclosed + (74) + (74+) Enclosed + (74) + (74+) Suspension + (169) + (169) e 1-Chloro-l,3-butadiene e f 2-Chloro-l,3-butadiene ' e Hexachloro-l,3-butadiene » a "Standard" refers to standard Ames Salmonella tests (plate incorporation or spot test); "Enclosed" refers to Salmonella tests carried out in desiccators or closed glass containers; "Suspension" refers to modified Salmonella tests in which bacteria and test chemical were pre-incubated in liquid suspension before plating.
In Osborne-Mendel rats, 1,2-dichlorethane (47 and 95 mg/kg/day, 5 days/week for 78 weeks) brought about a significant increase in the incidence of squamous cell carcinomas of the forestomach (control, 0%; lowdose, 6%; high-dose, 18%), hemangiosarcomas, and subcutaneous fibromas in males and of mammary adenocarcinomas (control, 0%; low-dose, 2%; high-dose, 36%) in females (256, 257). Also, by topical route, 1,2-dichloroethane (126 mg/application, 3 times/week for 440 to 594 days) was carcinogenic, inducing lung tumors in 26/30 female Swiss ICR/Ha mice; however, no local tumors were observed (216).
The most significant finding among studies of haloethanes is the potent carcinogenicity of 1,2-dibromoethane (ethylene dibromide). This compound is carcinogenic by topical, oral, or inhalational route. The closely related 1,2-dichloroethane is also carcinogenic (although less potent) by topical or oral administration but appears to be inactive via inhalation. In addition to 1,2dichloroethane, six other chlorinated ethanes have been investigated. The majority of these compounds have been shown to be carcinogenic in B6C3FJ mice but inactive in Osborne-Mendel or Fischer 344 rats.
Aliphatic and Polyhalogenated Carcinogens. Structural Bases and Biological Mechanisms by Yin-Tak Woo, David Y. Lai, Joseph C. Arcos
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